Association of Urine Albumin to Creatinine Ratio With Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus
Authors' conclusion
An elevated UACR is associated with a higher risk of MACEs and total mortality in patients with T2DM, even when it falls within the normal range. The UACR improves prediction of MACE and total mortality risk in patients with T2DM.
Study context
- Population
- Patients with T2DM in ACCORD and ACCORDION with baseline urinary albumin to creatinine ratio (UACR) data
- Participants
- 10,171 patients
- Comparison
- Association of UACR with MACE and total mortality
- Primary endpoint
- MACE and total mortality
- Follow-up
- Median 8.83 years
Methodological detailsunivariate and multivariate Cox proportional hazard regression
- Univariate and multivariate Cox proportional hazard regression
Primary result
As reported in the abstract
Participants with MACE
1808
17.78%
Total deaths
1934
19.01%
Further findings
Additional predictive value of UACR
- Adding UACR to the conventional risk model enhanced predictive efficacy for MACE and total mortality
Original publication
Association of Urine Albumin to Creatinine Ratio With Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 31 October 2023. doi:10.
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