Unraveling shared risk factors for diabetic foot ulcer: a comprehensive Mendelian randomization analysis
Authors' conclusion
Enhanced glycemic control and foot care are essential for the diabetic population with high BMI, limited education, smoking history, and indicators of poor nutrition. By focusing on these specific risk factors, healthcare interventions can be better tailored to prevent and manage DFU effectively.
Study context
- Population
- Genetic associations with diabetic foot ulcer (DFU), diabetic polyneuropathy (DPN) and diabetic peripheral artery disease (DPAD) from FinnGen and UK Biobank; 85 phenotypes in five categories as exposures
- Outcome
- Shared and distinct risk factors for DFU, DPN and DPAD
Methodological detailsgenome-wide significant genetic variants as instrumental variables, FinnGen and UK Biobank
- Genome-wide significant genetic variants as instrumental variables
- FinnGen and UK Biobank
Main finding
As reported in the abstract
- Body mass index (BMI) was the only significant risk factor for DPAD, DPN and DFU, independent of T2D, fasting glucose, fasting insulin and HbA1c
- Educational attainment was the sole significant protective factor against DPAD, DPN and DFU
- Glycemic traits below the T2D diagnosis threshold associated with DPAD and DPN
- Smoking history showed suggestive associations with DFU
- Indicators of poor nutrition (total protein, mean corpuscular hemoglobin, mean corpuscular volume) may signal potential DFU occurrence
Original publication
Unraveling shared risk factors for diabetic foot ulcer: a comprehensive Mendelian randomization analysis. BMJ Open Diabetes Res Care. Published 20 November 2023. doi:10.
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