Association of glycemic variability with death and severe consciousness disturbance among critically ill patients with cerebrovascular disease: analysis of the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
Authors' conclusion
High glycemic variability was found to be an independent risk factor for severe cognitive decline and in-hospital mortality in critically ill patients with CVD. Our study indicated that enhancing stability of glycemic variability may reduced adverse outcomes in patients with severe CVD.
Study context
- Population
- Critically ill patients with cerebrovascular disease (CVD) (cerebral infarction or non-traumatic cerebral hemorrhage) in MIMIC-IV2,967 infarction, 1842 hemorrhage
- Exposure
- Glycemic variability and outcomes
- Outcome
- Severe consciousness disturbance (cognitive impairment) and in-hospital all-cause mortality
- Follow-up
- In-hospital
Methodological detailsMIMIC-IV database, Cox hazard regression, restricted cubic spline analysis
- MIMIC-IV database
- Cox hazard regression
- Restricted cubic spline analysis
Main finding
As reported in the abstract
Cognitive impairment and in-hospital mortality
- Log-transformed coefficient of variation (CV) significantly related to cognitive impairment and in-hospital mortality (Cox regression)
- Approximately linear increase in risk of cognitive impairment and in-hospital mortality with increasing log-transformed CV
Observational data: associations, not effects.
Original publication
Association of glycemic variability with death and severe consciousness disturbance among critically ill patients with cerebrovascular disease: analysis of the MIMIC-IV database. Cardiovasc Diabetol. Published 16 November 2023. doi:10.
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