Association of glycemic variability with short and long-term mortality among critically ill patients with heart failure: Analysis of the MIMIC-IV database
Authors' conclusion
Our Study indicates that high GV may be an independent risk factor for short and long-term mortality in critically ill HF patients. Maintaining the stability of blood glucose can reduce adverse outcomes in critically ill HF patients.
Study context
- Population
- Critically ill patients with heart failure (HF), Medical Information Mart for Intensive Care IV database
- Participants
- 8,980 patients
- Exposure
- High vs low glycemic variability
- Outcome
- In-hospital and 1-year mortality
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
High GV vs Low GVEstimate (95 % CI)
In-hospital mortality; multifactorial regression
OR 1.69(1.47–1.93)
1-year mortality; multifactorial regression
HR 1.12(1.02–1.22)
Observational data: associations, not effects.
Further findings
Mediation of glycemic variability (GV) effect on in-hospital mortality by ventricular arrhythmias
- Proportion partially mediated by ventricular arrhythmias (VA)
- 4.98%
1-year mortality, by diabetes
- Increased risk with high GV more significant in persons with diabetes
- P for interaction = 0.018
Original publication
Association of glycemic variability with short and long-term mortality among critically ill patients with heart failure: Analysis of the MIMIC-IV database. Diabetes Res Clin Pract. Published 25 January 2025. doi:10.
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