Modification Effects of Albuminuria on the Association Between Kidney Function and Development of Anemia in Diabetes
Authors' conclusion
We revealed that the severity of albuminuria modified the association between eGFR and anemia development among individuals with eGFR <30 mL/min/1.73 m2, highlighting the modification effect of albuminuria on the association between kidney function and anemia development in diabetes.
Study context
- Population
- Adults with diabetes, Japanese nationwide clinical database (JMDC)data points from 48,056 individuals
- Participants
- 327,999 adults
- Exposure
- Albuminuria severity, stratified by estimated glomerular filtration rate (eGFR)
- Normoalbuminurian = 186,472reference
- Microalbuminurian = 107,170
- Macroalbuminurian = 34,357
- Outcome
- Prevalence of anemia (hemoglobin < 13 g/dL in men, < 12 g/dL in women), stratified by albuminuria severity after adjusting for eGFR
Methodological detailsnationwide clinical database, modified Poisson regression, marginal standardization
- Nationwide clinical database
- Modified Poisson regression
- Marginal standardization
Main finding
As reported in the abstract
Anemia prevalence by albuminuria severity and eGFR
Higher anemia prevalence with macroalbuminuria vs normoalbuminuria at eGFR <30 mL/min/1.73 m²
5% to 20%
Observational data: associations, not effects.
Original publication
Modification Effects of Albuminuria on the Association Between Kidney Function and Development of Anemia in Diabetes. J Clin Endocrinol Metab. Published 13 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →