U-500 regular insulin in automated insulin delivery systems for severe insulin resistance: A single-center retrospective cohort
Authors' conclusion
These findings provide early clinical experience to inform cautious, individualized off-label use.
Study context
- Population
- Individuals with severe insulin resistance using AID systems
- Participants
- 4 individuals
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- HbA1c remained stable
- TBR stayed low
- Lower TIR
Observational data: associations, not effects.
Safety
- No DKA or severe hypoglycemia occurred
Original publication
U-500 regular insulin in automated insulin delivery systems for severe insulin resistance: A single-center retrospective cohort. Diabetes Res Clin Pract. Published 26 July 2026. doi:10.
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