Type 2 diabetes remission and metabolic outcomes 5 years after Roux-en-Y gastric bypass in young vs older adults: a multicentre matched cohort study
Authors' conclusion
Diabetes remission occurred earlier and more frequently in young adults within the first 5 years after RYGB. Surgical complications, nutritional deficiency or suboptimal weight loss were not different in the investigated young adult group compared with the older adults.
Study context
- Population
- Adults with non-insulin-dependent T2D undergoing RYGB at three expert centresmatched cohort
- Participants
- 67 vs 134
- Exposure
- RYGB in young adults vs older adults
- Young adultsn = 67
- Older adultsn = 134reference
- Outcome
- Diabetes remission
- Follow-up
- 5 years postoperatively
Methodological detailsmulticentre, prospective registry data, matched 1:2 for duration of preoperative diabetes, sex, BMI and ASA physical status score
- Multicentre
- Prospective registry data
- Matched 1:2 for duration of preoperative diabetes, sex, BMI and ASA physical status score
Main finding
As reported in the abstract
HR for diabetes remission
2.92
95% CI 1.13–7.59
P = 0.027
By group
Young adultsvs Older adults
HR for diabetes remission 2.92 (95% CI 1.13–7.59); P = 0.027
Observational data: associations, not effects.
Further findings
Attendance at 5-year follow-up
Attendance at 5-year follow-up
- No significant difference in loss to follow-up between groups
Percentage weight change · 5 years
- No significant difference between groups
Safety
All-cause adverse events · 5 years
- No significant difference between groups
Original publication
Type 2 diabetes remission and metabolic outcomes 5 years after Roux-en-Y gastric bypass in young vs older adults: a multicentre matched cohort study. Diabetologia. Published 29 January 2026. doi:10.
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