Gastric bypass elicits persistent gut adaptation and unique diabetes remission‐related metabolic gene regulation
Authors' conclusion
RL adaptation is a key feature of RYGB in all patients, likely reflecting the dramatic alterations to gastrointestinal anatomy, but jejunal lipogenesis appears to be more strongly activated in those patients with diabetes remission. Further study is needed to understand whether these pathways may drive metabolic remission after RYGB.
Study context
- Population
- Patients undergoing RYGB; jejunum (Roux limb) sampled before and 12 months after surgery
- Participants
- 28 patients
- Outcome
- Jejunal (Roux limb) gene expression
- Follow-up
- 12 months after RYGB
Methodological detailspaired baseline and 1-year jejunal samples, RNA sequencing
- Paired baseline and 1-year jejunal samples
- RNA sequencing
Main finding
As reported in the abstract
Gene expression (GE) consistent with persistent Roux limb remodeling; microvilli elongated
39%
Original publication
Gastric bypass elicits persistent gut adaptation and unique diabetes remission‐related metabolic gene regulation. Obesity (Silver Spring). Published 15 October 2024. doi:10.
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