Gut adaptation after gastric bypass in humans reveals metabolically significant shift in fuel metabolism
Authors' conclusion
These data support a role for a direct effect of intestinal energy metabolism to contribute to the beneficial clinical effects of RYGB, suggesting that related pathways might be potential targets of therapeutic interest for patients with obesity with or without type 2 diabetes.
Study context
- Population
- Patients with and without diabetes undergoing RYGB; Roux limb tissue collected surgically/endoscopically across six postoperative months
- Participants
- 19 patients
- Outcome
- Roux limb gene expression
- Follow-up
- Six postoperative months, incl. early (1 month ± 15 days)
Methodological detailsfirst-in-human, microarray gene expression
- First-in-human
- Microarray gene expression
Main finding
As reported in the abstract
- Roux limb (RL) gene expression (GE) showed tissue remodeling and metabolic reprogramming, incl. increased glucose and amino acid use
- RL GE signatures established early, before maximal clinical response, and persisted
- Distinct GE fingerprints predicted concurrent and future improvements in HbA1c and weight
- RL GE changes characterized by anabolic growth and shift in metabolic substrate use
- Anabolic growth in RL appeared to contribute to the catabolic state elicited by RYGB
Observational data: associations, not effects.
Original publication
Gut adaptation after gastric bypass in humans reveals metabolically significant shift in fuel metabolism. Obesity (Silver Spring). Published 21 December 2022. doi:10.
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