Fat content in infant mesenchymal stem cells prospectively associates with childhood adiposity and fasting glucose
Authors' conclusion
This work demonstrates the strength of the MSC model for predicting offspring metabolic phenotype into childhood, even when considering the important contribution of other early life risk factors.
Study context
- Population
- Mother/child dyads; infant umbilical cord-derived mesenchymal stem cells (MSCs) undergoing adipogenesis in vitro
- Participants
- 124 mother/child dyads
- Outcome
- Association of MSC triglyceride content (MSC-TG) with in vivo adiposity (percent fat mass) from birth to early childhood and with fasting glucose and insulin in early childhood
Methodological detailsmechanistic, mother/child dyads
- Mechanistic
- Mother/child dyads
Main finding
As reported in the abstract
MSC-TG vs in vivo child adiposity, fasting glucose and insulin
Additional variance in child adiposity at 4 to 6 years explained by MSC-TG, after accounting for birth weight, % fat mass at birth and covariates (e.g., breastfeeding, physical activity)
13%
Observational data: associations, not effects.
Original publication
Fat content in infant mesenchymal stem cells prospectively associates with childhood adiposity and fasting glucose. Obesity (Silver Spring). Published 21 December 2022. doi:10.
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