Myogenically differentiated mesenchymal stem cell insulin sensitivity is associated with infant adiposity at 1 and 6 months of age
Authors' conclusion
Exposure to any type of exercise in utero improves offspring SI and could reduce adiposity in early infancy.
Study context
- Population
- Pregnant females <16 weeks' gestation; umbilical cord MSCs myogenically differentiated at delivery
- Comparison
- Maternal exercise vs nonexercising control
- Primary endpoint
- Insulin sensitivity (SI) and fatty acid oxidation (FAO) of myogenically differentiated umbilical cord MSCs
- Follow-up
- Delivery
Primary result
As reported in the abstract
MSC SI
- MSCs from infants of all exercisers had significantly higher SI
- p < 0.05
Further findings
Association of MSC SI with infant BF% · 1 and 6 months
- MSC SI inversely associated with infant BF% at 1 month
- r = −0.38, p < 0.05
- MSC SI inversely associated with infant BF% at 6 months
- r = −0.65, p < 0.01
Infant BF% in high vs low SI · 1 and 6 months
- Infants with high SI had lower BF% at 1 month
- P = 0.06
- Infants with high SI had lower BF% at 6 months
- P < 0.01
MSC fatty acid oxidation (FAO) in high SI group
- MSCs in the high SI group had higher FAO
- P < 0.05
Original publication
Myogenically differentiated mesenchymal stem cell insulin sensitivity is associated with infant adiposity at 1 and 6 months of age. Obesity (Silver Spring). Published 8 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →