Challenges of considering both extremities of the weight status spectrum to better understand obesity: insights from the NUTRILEAN project in constitutionally thin individuals
Authors' conclusion
The present work encourages investigators to adopt a high level of rigour despite the complexity and duration of recruitment processes for this specific population, and readers to pay close attention to the quality of recruitment when interpreting the data. To better understand obesity and its physiological adaptations, it seems essential not only to compare it to normal-weight conditions, but also to the other extremity of the weight status spectrum represented by constitutional thinness.
Study context
- Population
- Publications about constitutional thinness (underweight without eating disorders)
- Outcome
- Level of rigour and quality of recruitment processes, assessed by a new grading system
Methodological detailsexpert-created grading system
- Expert-created grading system
Main finding
As reported in the abstract
Quality of recruitment processes
- Metabolic-related biasing criteria were poorly observed despite being crucial
- Recruitment processes were not detailed enough or sufficiently explicit
- Recruiting among already identified patients was associated with higher sample sizes and better quality scores
Original publication
Challenges of considering both extremities of the weight status spectrum to better understand obesity: insights from the NUTRILEAN project in constitutionally thin individuals. Int J Obes (Lond). Published 8 August 2023. doi:10.
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