Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes
Authors' conclusion
Individuals with increased genetic risk of T2D have a higher risk of glucocorticoid-induced hyperglycemia. This finding offers a mechanism for risk stratification as part of a precision approach to medical treatment.
Study context
- Population
- Individuals with no diagnosis of diabetes who received a glucocorticoid dose of ≥10 mg prednisone210 with hyperglycemia
- Participants
- 546 individuals
- Exposure
- Association of T2D polygenic score with glucocorticoid-induced hyperglycemia
- Outcome
- Glucocorticoid-induced hyperglycemia
Main finding
As reported in the abstract
Glucocorticoid-induced hyperglycemia per SD of T2D global extended polygenic score
OR per SD of polygenic score (P = 0.038)
1.4
Developed hyperglycemia
210 of 546
Observational data: associations, not effects.
Original publication
Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes. Diabetes Care. Published 23 June 2023. doi:10.
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