Association of Body Mass Index and Its Change With Incident Diabetes Mellitus
Authors' conclusion
Our findings offer novel insights into improving an optimal bodyweight management strategy to prevent the development of DM.
Study context
- Population
- Individuals without prior diabetes mellitus (DM) or glucose-lowering medication use, JMDC Claims Database; median age 44 years, 57.5% men
- Participants
- 3,400,303 individuals
- Exposure
- Body mass index (BMI) change ≥+5.0% or ≤−5.0% vs stable BMI over 1 year
- Outcome
- Incident DM
Methodological detailsobservational, claims database (JMDC), 2005–2021
- Observational
- Claims database (JMDC), 2005–2021
Main finding
As reported in the abstract
Incident DM by BMI change
Each group vs −5.0% to +5.0%Relative risk (95% CI)
≥+5.0%
1.33(1.31–1.36)
≤−5.0%
0.82(0.80–0.84)
Observational data: associations, not effects.
Further findings
BMI reduction by baseline BMI category (underweight, normal weight, overweight, obese)
- Reducing BMI lowered DM risk in normal weight, overweight and obese people, but raised DM risk in underweight people
Original publication
Association of Body Mass Index and Its Change With Incident Diabetes Mellitus. J Clin Endocrinol Metab. Published 23 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →