Type 2 diabetes mellitus is not associated with a clinically relevant exocrine pancreatic phenotype: A prospective multimodal assessor-blinded case-control study
Authors' conclusion
In this selected EUS-referred population without known or suspected pancreatic disease, T2DM was not associated with clinically relevant exocrine dysfunction, pancreatic atrophy or a coherent chronic pancreatitis-like EUS phenotype.
Study context
- Population
- Adults undergoing endoscopic ultrasound (EUS) for non-pancreatic indications, without known or suspected pancreatic disease57 T2DM, 53 controls analysed
- Participants
- 57 vs 53
- Comparison
- T2D vs non-diabetic controls
- T2DMn = 57
- Controlsn = 53reference
- Outcome
- Number of EUS abnormalities
Methodological detailsassessor-blinded, multimodal, frequency-matched by sex and age, adjusted models, EUS performed by endosonographers blinded to diabetes status
- Assessor-blinded
- Multimodal
- Frequency-matched by sex and age
- Adjusted models
- EUS performed by endosonographers blinded to diabetes status
Main finding
As reported in the abstract
T2DM
2.16
± 1.97
Controls
1.77
± 2.02
P = 0.186
Observational data: associations, not effects.
Further findings
≥ 5 EUS abnormalities
P = 0.701
Low FE-1 < 200 µg/g
Low FE-1 < 200 µg/g
- Low FE-1 not more frequent in T2DM
Pancreatic body diameter, mean strain ratio, FE-1, GIQLI, PEI-Q, nutritional markers
- Comparable between groups
Symptoms
- Early satiety and diarrhoea more frequent in T2DM
Original publication
Type 2 diabetes mellitus is not associated with a clinically relevant exocrine pancreatic phenotype: A prospective multimodal assessor-blinded case-control study. Diabetes Res Clin Pract. Published 19 September 2026. doi:10.
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