Type 1 Diabetes Mellitus and Lipohypertrophy - Impact of the Intervention on Glycemic Control via Patient’s Examination and Retraining on Change of Infusion Set
Authors' conclusion
The structured LH-related intervention in patients with T1DM on insulin pumps resulted in better glycemic control and a decrease in total daily insulin dose.
Study context
- Population
- Consecutive patients with T1D on control on subcutaneous insulin infusion (CSII); follow-up cohort median age 29 years, 50% women, T1D duration 16.5 years46 in follow-up
- Participants
- 79 patients
- Comparison
- After vs before lipohypertrophy (LH) assessment and retraining on infusion set use
- Interventionn = 79
- Outcome
- HbA1c
- Follow-up
- Baseline to median 22 weeks (20-31.75 weeks)
Methodological detailssingle-group, consecutive patients
- Single-group
- Consecutive patients
Main finding
As reported in the abstract
Median HbA1c fell from baseline to follow-up
7.4% (6.7%-8.2%) to 7.05% (6.4%-7.6%)
Further findings
- Daily insulin dose/kg · baseline to follow-up — Daily insulin dose/kg decreased · follow-up vs baseline
- 0.7 ± 0.20 vs 0.68 ± 0.15 IU/kg · P = 0.017
- Total daily insulin dose · baseline to follow-up — Total daily insulin dose decreased · follow-up vs baseline
- 50.3 [40.5-62.7] vs 47.6 [39.8-62.1] IU · P = 0.019
- Percentage of basal insulin dose · baseline to follow-up — Percentage of basal insulin dose increased · follow-up vs baseline
- 43.0% [36-50] vs 44.0% [39.0-50.0] · P = 0.010
- Percentage of bolus dose · baseline to follow-up — Percentage of bolus dose decreased · follow-up vs baseline
- 57% [50-64] vs 56% [50-61] · P = 0.010
Original publication
Type 1 Diabetes Mellitus and Lipohypertrophy - Impact of the Intervention on Glycemic Control via Patient’s Examination and Retraining on Change of Infusion Set. Endocr Pract. Published 27 December 2022. doi:10.
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