Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients
Authors' conclusion
TyG index was associated with the incidence of obstructive CAD in hypertensive patients.
Study context
- Population
- Hypertensive subjects without history of coronary artery disease (CAD) who underwent coronary CT angiography (coronary computed tomography angiography (CCTA)) for chest pain
- Participants
- 1,841 subjects
- Exposure
- TyG index tertiles T3 and T2 vs T1
- Outcome
- Obstructive CAD (OCAD): diameter stenosis ≥ 50% in any of the four major epicardial coronary arteries on CCTA
Main finding
As reported in the abstract
OCAD by TyG tertile
Adjusted risk (times as high)
2.12
95% CI 1.80–3.81P for trend = 0.001
T3
Adjusted risk (times as high)
2.01
95% CI 1.40–2.88P for trend = 0.001
T2
- Patients who developed obstructive CAD
- 310 (16.8%)
Observational data: associations, not effects.
Further findings
Obstructive CAD (OCAD) per 1-SD increase in TyG (continuous)
- OR per 1-SD increase
- 1.49 (95% CI 1.30-1.74), p = 0.007
Restricted cubic spline (RCS) analysis: TyG and OCAD
- J-shaped relationship; OR perSD for OCAD as TyG rose over 8.61
- 1.64, 95% CI 1.13-2.54, p = 0.008
Subgroups
- Positive effect consistent across subgroups
- P for interaction > 0.05
Original publication
Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients. Cardiovasc Diabetol. Published 12 January 2023. doi:10.
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