Triglyceride-glucose index is associated with poor prognosis in acute coronary syndrome patients with prior coronary artery bypass grafting undergoing percutaneous coronary intervention
Main finding · MACCEResult — go to the resultHazard ratio 1.53 95% CI 1.16–2.01Authors' conclusion
The TyG index is independently associated with MACCE, suggesting that the TyG index may serve as a valid indicator for predicting poor prognosis in ACS patients with prior CABG undergoing PCI.
Study context
- Population
- Acute coronary syndrome (ACS) patients with prior coronary artery bypass grafting (CABG) undergoing percutaneous coronary intervention (PCI)
- Participants
- 1,158 patients
- Exposure
- High vs low triglyceride-glucose (TyG) index
- Outcome
- MACCE: composite of all-cause death, nonfatal MI, nonfatal stroke and unplanned repeat revascularization
- Follow-up
- median 42-month follow-up
Main finding
MACCE
Hazard ratio
1.53
95% CI 1.16–2.01
P = 0.003
By group
High TyG indexvs Low TyG index
HR 1.53 (95% CI 1.16–2.01); P = 0.003
As reported in the abstract
- Patients with ≥1 endpoint event, overall
- 350 (30.2%)
Observational data: associations, not effects.
Further findings
MACE
P = 0.003
Nonfatal stroke
P = 0.022
Unplanned repeat revascularization
P < 0.001
Shape of TyG index–major adverse cardiovascular and cerebrovascular events (MACCE) relationship (restricted cubic spline)
- Linear relationship
- p for non-linear = 0.595, p for overall = 0.005
Prediction of MACCE (AUC)
- AUC baseline risk model
- 0.618
- AUC baseline risk model + TyG index groups
- 0.636
- Improvement in accuracy
- p for comparison = 0.042
Original publication
Triglyceride-glucose index is associated with poor prognosis in acute coronary syndrome patients with prior coronary artery bypass grafting undergoing percutaneous coronary intervention. Cardiovasc Diabetol. Published 27 October 2023. doi:10.
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