Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes
Authors' conclusion
Capillaroscopic and photoplethysmographic examinations are non-invasive, painless, fast, and inexpensive. They are devoid of side effects, and there are no limitations in the frequency of their use and repetition. The usefulness of capillaroscopy and photoplethysmography in the study of microcirculation in diabetic patients indicates the vast application possibilities of these methods in clinical practice.
Study context
- Population
- Children and adolescents aged 6–18 with T1D and healthy volunteers
- Participants
- 160 children
- Exposure
- Children with T1D vs healthy controls
- T1Dn = 125
- Healthy controlsn = 35reference
- Outcome
- Nailfold capillaroscopy findings
Main finding
As reported in the abstract
- T1D vs Healthy controls: P = 0.019
- T1D vs Healthy controls: P = 0.006
- T1D vs Healthy controls: P = 0.026
Observational data: associations, not effects.
Further findings
Meandering capillaries and nutritional status
- Meandering capillaries correlated with higher parameters of nutritional status
Photoplethysmography in patients with diagnosed neuropathy
- Higher percentage of flow disturbance curves with neuropathy
- P < 0.001
- Reduced frequency of normal curves with neuropathy
- P = 0.050
Original publication
Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes. Cardiovasc Diabetol. Published 21 October 2023. doi:10.
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