Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study
Authors' conclusion
There is positive familial (co-)aggregation of cardiometabolic disorder, moderate heritability of intermediate traits, and moderate genetic correlations between traits. These results indicate that shared genetics and common genetic architecture contribute to cardiometabolic disease.
Study context
- Population
- Participants of the multi-generational Lifelines Cohort Study (baseline data); disorders defined in adults
- Participants
- 162,416 participants
- Exposure
- First-degree relatives (FDR) vs spouses of individuals with cardiometabolic disorders
- Outcome
- Familial (co-)aggregation of cardiometabolic disorders (recurrence risk ratios, λR, in FDR) and heritability and genetic correlations of cardiometabolic traits
Methodological detailsmulti-generational, family-based
- Multi-generational
- Family-based
Main finding
As reported in the abstract
Familial aggregation: risk of same disorder with an affected FDR (λFDR)
- λFDR, hypertension (lowest)
- 1.23 (95% CI 1.20-1.25)
- λFDR, T2D (highest)
- 2.48 (95% CI 2.15-2.86)
- Heritability of cardiometabolic traits, from h2 CRP to h2 HDL
- 0.26 to 0.50
- Familial co-aggregation, from λFDR obesity-MetS 1.28 (95% CI 1.24-1.32) to λFDR MetS-T2D 1.61
- 1.28 to 1.61 (95% CI 1.52-1.70)
- Genetic correlations, from rg HDL-triglycerides to rg LDL-apolipoprotein B
- - 0.53 to 0.94
Observational data: associations, not effects.
Original publication
Familial co-aggregation and shared genetics of cardiometabolic disorders and traits: data from the multi-generational Lifelines Cohort Study. Cardiovasc Diabetol. Published 21 October 2023. doi:10.
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