The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross‐sectional study
Authors' conclusion
The intrinsic adipogenic potential of SAT is not affected by a family history of T2DM. However, alterations in LOX mRNA and polyunsaturated fatty acids in triacylglycerols are likely related to the risk of developing T2DM independent of obesity.
Study context
- Population
- Individuals without obesity (fat mass < 25%): First-degree relatives (FDR) of T2D patients and controls
- Participants
- 19 vs 19
- Exposure
- First-degree relatives of T2D patients vs controls, without obesity
- FDRn = 19
- Controln = 19reference
- Outcome
- Adipogenic capacity of SAT-derived adipose precursors
Main finding
As reported in the abstract
- Subcutaneous adipose tissue (SAT)-derived adipose precursors did not differ in ability to proliferate and differentiate or in metabolic parameters (lipolysis, mitochondrial oxidation)
Observational data: associations, not effects.
Further findings
Insulin sensitivity and visceral fat
- FDR had lower insulin sensitivity (IS) and higher amount of visceral fat vs controls
SAT lipidome and mRNA expression
- In SAT of FDR: accumulation of TG containing polyunsaturated fatty acids and increased lysyl oxidase (LOX) mRNA expression
- These parameters correlated with IS, visceral fat accumulation and mRNA expression of inflammatory and cellular stress genes
Original publication
The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross‐sectional study. Obesity (Silver Spring). Published 14 January 2024. doi:10.
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