Triglyceride-glucose index is associated with severe obstructive coronary artery disease and atherosclerotic target lesion failure among young adults
Main finding · Prevalent EOCADResult — go to the resultAdjusted odds ratio 1.40 95% CI 1.23–1.60Authors' conclusion
TyG index is positively associated with prevalent EOCAD and incident TLF. TyG index appeared to be a valuable component of future efforts to improve CAD risk stratification and TLF outcome prediction among young adults.
Study context
- Population
- Young adults aged ≤45 years, 38 hospitals in China, 2017–2020; EOCAD patients 39.6 ± 4.4 years, 95.4% male; controls 39.0 ± 4.4 years, 46.4% male
- Participants
- 1,513 vs 1,513
- Comparison
- Triglyceride-glucose (TyG) index
- EOCADn = 1,513
- Controlsn = 1,513reference
- Outcome
- Association of TyG index with prevalent EOCAD and incident TLF after successful PCI
Methodological detailsmulticentre, age-matched controls
- Multicentre
- Age-matched controls
Main finding
Prevalent EOCAD
Adjusted odds ratio
1.40
95% CI 1.23–1.60
TyG index per SD increase
aOR 1.40 (95% CI 1.23–1.60)
Per SD increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Incident TLF · median 33 month (IQR: 31-34 months)Top TyG index tertilevs Bottom TyG index tertile | aHR 2.410 (95% CI 1.07–5.42) | |
| Incident TLF · median 33 month (IQR: 31-34 months)TyG index per SD increase | HR 1.30 (95% CI 1.01–1.73) | |
| 0.20.5125Ratio (log scale) |
- Incident target lesion failure (TLF) — Patients with TLF
- 43 (3.3%)
Diagnostic ability for EOCAD with TyG index added to empirical risk model
- Net reclassification improvement 0.10 (95% CI 0.03-0.17)
- P = 0.005
AUC to predict TLF: conventional risk factors vs plus TyG index
- AUC improved
- 0.722-0.734, p = 0.04
Original publication
Triglyceride-glucose index is associated with severe obstructive coronary artery disease and atherosclerotic target lesion failure among young adults. Cardiovasc Diabetol. Published 21 October 2023. doi:10.
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