Tissue-specific inflammation and insulin sensitivity in subjects with obesity
Authors' conclusion
Our results show that obesity is characterised by systemic and tissue-specific inflammation. Subjects with obesity and IR show a more pronounced inflammation phenotype, independent of BMI. Bariatric surgery-induced weight loss is associated with reduced inflammation and improved metabolic health.
Study context
- Population
- Subjects with obesity (and normal-weight women) across three cohorts: 6 women with normal weight and 20 with obesity; 24 women with obesity in upper vs lower insulin sensitivity quartile; 23 women and 18 men with obesity before and 1 year after bariatric surgerythree cohorts
- Outcome
- Tissue-specific inflammation and insulin sensitivity
Methodological detailsthree cohorts
- Three cohorts
Main finding
As reported in the abstract
- Cohort 1, women with obesity: upregulation of inflammatory markers in subcutaneous and visceral adipose tissue (AT), isolated AT macrophages and liver, but no linear correlation with tissue-specific insulin sensitivity
- Cohort 3, before and one year after bariatric surgery: weight loss associated with downregulation of multiple immune pathways in subcutaneous AT and skeletal muscle, with notable metabolic improvements
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Tissue-specific inflammation and insulin sensitivity in subjects with obesity. Diabetes Res Clin Pract. Published 12 April 2024. doi:10.
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