Metabolic Effects of Testosterone Added to Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism
Authors' conclusion
In older men with obesity and hypogonadism, adding TRT for 6 months to LT does not result in further improved cardiometabolic profiles and could potentially blunt some of the metabolic benefits induced by LT.
Study context
- Population
- Older (age ≥ 65 years) men with obesity (BMI ≥ 30 kg/m²) and persistently low Am testosterone (< 10.4 nmol/L) associated with frailty; Veterans Affairs Medical Center
- Participants
- 83 participants
- Comparison
- Testosterone replacement therapy (TRT) vs placebo added to intensive lifestyle therapy
- Primary endpoint
- Change in HbA1c
- Follow-up
- 6 months
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Lifestyle therapy (LT) + TRT
−0.5
± 0.1 · %
LT + Pbo
−0.6
± 0.1 · %
P = 0.35
Secondary outcomes
| Outcome | LT + TRT | LT + Pbo | P value |
|---|---|---|---|
| Change in HDL-C · 6 monthsTRT eliminated the augmentative effect of LT | 0.2 ± 1.1 mg/dL | 5.4 ± 1.0 mg/dL | P = 0.01 |
| Change in adiponectin · 6 monthsTRT eliminated the augmentative effect of LT | −408 ± 489 ng/mL | 1832 ± 468 ng/mL | P = 0.02 |
Other secondary outcomes
- TRT showed no synergistic effect with LT on ameliorating secondary outcomes
Original publication
Metabolic Effects of Testosterone Added to Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism. J Clin Endocrinol Metab. Published 12 April 2024. doi:10.
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