Time Trends in Liver-Related Mortality in People With and Without Diabetes: Results From a Population-Based Study
Authors' conclusion
While liver-related mortality rates decreased significantly among patients with diabetes, NVNA causes made up the majority of cases. Excess mortality for liver-related causes in patients with diabetes compared with controls remained constant in the studied period.
Study context
- Population
- General population of Lombardy, Italy (about 16%, almost 10 million, of Italy's population), 2010–2019
- Exposure
- People with diabetes vs without diabetes
- Outcome
- Time trends in cause-specific liver-related mortality (viral, alcohol related, NVNA)
- Follow-up
- 2010 to 2019
Methodological detailshealth care utilization databases, time-trend analysis 2010–2019
- Health care utilization databases
- Time-trend analysis 2010–2019
Main finding
As reported in the abstract
Liver-related mortality, people with diabetes
- Crude liver disease mortality rate in diabetes, 2010 to 2019
- 1.13 to 0.64 deaths per 1000 person-years
- NVNA share of liver-related deaths, 2010 to 2019
- 63% to 68%
- Viral share of liver-related deaths, 2010 to 2019
- 27% to 23%
- SMR in diabetes, NVNA
- 3.35 (95% CI 2.96-3.76)
- SMR in diabetes, viral hepatitis
- 1.66 (95% CI 1.33-2.01)
- SMR in diabetes, alcoholic liver disease
- 1.61 (95% CI 1.13-2.17)
Observational data: associations, not effects.
Further findings
Share of deaths due to liver diseases · 2019
Excess mortality risk in diabetes: liver-related vs CVD and cancer
- Excess liver-related mortality risk in diabetes was higher than for CVD mortality and cancer
Original publication
Time Trends in Liver-Related Mortality in People With and Without Diabetes: Results From a Population-Based Study. J Clin Endocrinol Metab. Published 20 March 2024. doi:10.
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