Time‐Restricted Eating Promotes Weight Loss and Favorable Changes in Adipose in Obesity: The TREAD Randomized Control Trial
Primary result · Change in weight from baseline to end of studyResult — go to the resultBetween-group difference −2.91 kg CI −4.21 to −1.60Authors' conclusion
In adults with obesity, compared with SOC dietary counseling alone, TRE promotes weight loss, healthier body composition, and, in exploratory analyses, reduction in adipose tissue proinflammatory gene expression.
Study context
- Population
- Adults with obesity (BMI 30–50 kg/m²) without diabetes and baseline eating window ≥ 14 h/day; mean age 55 ± 12.1 years, 58% women, BMI 35.5 ± 4.8 kg/m²52 completed
- Participants
- 61 adults
- Comparison
- 10-h time-restricted eating (TRE) vs standard of care
- TREn = 26
- Standard of care (SOC)n = 26reference
- Primary endpoint
- Change in weight (kg)
- Follow-up
- 12 weeks
Methodological detailssingle-center, 1:1 randomization
- Single-center
- 1:1 randomization
Primary result
Change in weight from baseline to end of study
Between-group difference
−2.91 kg
CI −4.21 to −1.60
P < 0.001
Change by group
TRE
−4.59
mean · 95% CI −5.51–-3.67 · kg
SOC
−1.68
mean · 95% CI −2.59–-0.77 · kg
TREvs SOC
between-group difference −2.91 kg (CI −4.21 to −1.60); P < 0.001
As reported in the abstract
Further findings
Adipose tissue gene expression (exploratory RNA-seq, subgroup)
- Downregulation of proinflammatory genes in adipose tissue during TRE
- Exploratory
Original publication
Time‐Restricted Eating Promotes Weight Loss and Favorable Changes in Adipose in Obesity: The TREAD Randomized Control Trial. Obesity (Silver Spring). Published 2 June 2026. doi:10.
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