Dietary intake of polybrominated diphenyl ethers (PBDEs) and the risk of obesity in the French E3N cohort
Authors' conclusion
This study identified a positive association between intake of PBDEs and the risk of overweight, obesity and weight gain.
Study context
- Population
- Women of the French E3N cohort, mean age 52.47 years, 20-years follow-up
- Participants
- 66,467 women
- Exposure
- Higher vs lower dietary PBDEs intake
- Outcome
- Risk of obesity, overweight and weight gain >10 kg
- Follow-up
- 20-years follow-up
Methodological detailsCox proportional hazard regression
- Cox proportional hazard regression
Main finding
As reported in the abstract
Overweight
Hazard ratio (CI)P value
1-SD increment
1.07(1.05–1.09)
Q4vs Q1
1.13(1.07–1.19)
P < 0.001for trendObservational data: associations, not effects.
Further findings
Weight gain >10 kg
| HR (CI) | ||
|---|---|---|
| 1-SD increment | 1.12 (1.09–1.14) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Weight gain >10 kgQ4vs Q1 | 1.28 (1.21–1.37) | P for trend < 0.001 | |
| Obesity | 1.25 (1.15–1.37) | P for trend < 0.001 | |
| 0.512Hazard ratio (log scale) |
- Obesity — Non-linear association between PBDEs intake and obesity risk
- P-non-linearity = 0.0014, P-overall <0.001
Sensitivity analyses
- Associations consistent after additional adjustment for total fat, polyunsaturated fatty acids (PUFA), n-3 PUFA, main food sources of PBDEs, and in analyses stratified by follow-up duration
Original publication
Dietary intake of polybrominated diphenyl ethers (PBDEs) and the risk of obesity in the French E3N cohort. Int J Obes (Lond). Published 2 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →