Time in Tight Glucose Range in Type 1 Diabetes: Predictive Factors and Achievable Targets in Real-World Users of the MiniMed 780G System
Authors' conclusion
This study demonstrates that 1) mean TIR is high with a high mean TITR in MM780G users (>48%), 2) consistent use of optimal GT/AIT improves TITR (>56%), 3) the impact of these settings on TITR is larger than on TIR, and 4) a TITR target >50% is our suggested treatment goal.
Study context
- Population
- Real-world users of the MiniMed 780G system with T1D, CareLink Personal data August 2020 to December 2022
- Participants
- 13,461 users
- Exposure
- Age ≤15 years vs Age >15 years
- Age ≤15 yearsn = 3,762
- Age >15 yearsn = 9,699
- Outcome
- Time in tight range (TITR) (70-140 mg/dL)
Methodological detailsreal-world CareLink Personal data
- Real-world CareLink Personal data
Main finding
As reported in the abstract
Average TITR (70-140 mg/dL) Age ≤15 years average 48.9% · Age >15 years average 48.8%
TIR
Observational data: associations, not effects.
Further findings
TITR in users consistently applying optimal settings (GT 100 mg/dL, AIT 2 h)
Relative impact of settings on TITR greater than on TIR
TITR best associated with GMI <7.0%, <6.8% and <6.5%
GMI <7.0%
GMI <6.8%
GMI <6.5%
Users achieving TITR >45%, >50% and >55% at optimal settings
TITR >45%
TITR >50%
TITR >55%
Factors predicting higher time in tight range (TITR)
- Consistent use of glucose target (GT) of 100 mg/dL and active insulin time of 2 h were the most relevant factors predicting higher TITR
- P < 0.0001
Original publication
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