Thyroid axis adaptations to moderate short-term energy restriction in healthy, young women
Authors' conclusion
Adaptive central and peripheral changes in thyroid hormones occur after short-term, moderate dieting in young women without obesity.
Study context
- Population
- Healthy women aged 23.36 ± 2.08 yr (mean ± SD) without obesity or thyroidal diseaseeach underwent both diets
- Participants
- 19 women
- Comparison
- Deficient energy availability diet vs neutral energy availability diet
- Primary endpoint
- Thyroid hormone change after short-term, moderate energy restriction
- Follow-up
- After 5 days
Methodological details5-day diets in early follicular phases of successive menstrual cycles, LC-MS/MS thyroid hormone assays, Blood sampled every 10 min between 8 AM and 4 PM
- 5-day diets in early follicular phases of successive menstrual cycles
- LC-MS/MS thyroid hormone assays
- Blood sampled every 10 min between 8 AM and 4 PM
Primary result
As reported in the abstract
TT3
P < 0.0001
Further findings
TSH · after 5 days · declined after DEA
P < 0.0001
TT4 · after 5 days · increased after DEA
P = 0.005
FT4 · after 5 days · increased after DEA
P = 0.0052
rT3 · after 5 days · increased after DEA
P < 0.0001
BMI and body weight after DEA · after 5 days
- Decrease in BMI after DEA (mean difference ± SEM), P < .001
- 0.4 ± 0.08 kg/m²
- Decrease in body weight after DEA (mean difference ± SEM), P < .001
- 1.1 ± 0.21 kg
- Fat mass unchanged
TBG, GH and cortisol · after 5 days
- No change in TBG, GH and cortisol after DEA
Original publication
Thyroid axis adaptations to moderate short-term energy restriction in healthy, young women. Eur J Endocrinol. Published 23 April 2025. doi:10.
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