Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes
Authors' conclusion
In conclusion, the three-protein signature identified may provide insights into mechanisms underlying depressive symptoms in diabetes and might open new therapeutic avenues.
Study context
- Population
- Adults with known diabetes duration <1 year from the German Diabetes Study (GDS)305 with ≥3 time points
- Participants
- 430 adults
- Exposure
- Associations of 135 inflammatory and neurological protein biomarkers with depressive symptoms
- Outcome
- Baseline CES-D score (continuous) and persistent/recurrent depressive symptoms
- Follow-up
- Baseline and annually over 5 years
Main finding
As reported in the abstract
Three-protein signature and baseline CES-D score and persistent/recurrent depressive symptoms (adjusted for covariates)
- CDCP1, baseline CES-D score: β
- 1.24 (0.19 to 2.29) (95% CI)
- SIRT2, baseline CES-D score: β
- 0.89 (0.06 to 1.72) (95% CI)
- Leptin receptor (LEPR), baseline CES-D score: β
- −0.99 (−1.87 to −0.11) (95% CI)
- CDCP1, persistent/recurrent depressive symptoms: OR
- 1.58 (1.08 to 2.31) (95% CI)
- SIRT2, persistent/recurrent depressive symptoms: OR
- 1.32 (1.03 to 1.71) (95% CI)
- LEPR, persistent/recurrent depressive symptoms: OR
- 0.70 (0.49 to 0.99) (95% CI)
Observational data: associations, not effects.
Original publication
Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes. BMJ Open Diabetes Res Care. Published 18 February 2025. doi:10.
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