Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes
Main finding · HL-PDFF, relative change corrected for time course without COVID-19Result — go to the resultRelative increase 56% 95% CI 18%–106%Authors' conclusion
History of COVID-19 in persons with type 2 diabetes is associated with higher HL-PDFF after 1 year following recovery from infection.
Study context
- Population
- Persons with T2D; COVID-19: age 58±12 years, BMI 30.9±5.2 kg/m²; no COVID-19: 61±6 years, 30.0±4.6 kg/m²
- Participants
- 15 vs 14
- Exposure
- T2D with history of mild COVID-19 vs T2D without COVID-19 over the same time course
- COVID-19n = 15
- No COVID-19n = 14reference
- Outcome
- Hepatic lipid content measured as proton density fat fraction (HL-PDFF)
- Follow-up
- 1 year (12±2 months) after recovery
Methodological detailsbefore–after comparison, control group without COVID-19, MR-based measurements
- Before–after comparison
- Control group without COVID-19
- MR-based measurements
Main finding
As reported in the abstract
HL-PDFF, relative change corrected for time course without COVID-19 · 1 year after recovery
Relative increase
56%
95% CI 18%–106%
P = 0.04
COVID-19vs No COVID-19
relative increase 56% (95% CI 18%–106%); P = 0.04
Observational data: associations, not effects.
Further findings
Hepatic stiffness and volume, intramyocellular lipids, whole-body, subcutaneous and visceral adipose tissue volumes, HOMA-IR and beta-cell function · 1 year after recovery
- No changes observed
Original publication
Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes. BMJ Open Diabetes Res Care. Published 18 February 2025. doi:10.
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