The role of sex and ethnicity in the variability of estimated glomerular filtration rate ( estimated glomerular filtration rate (eGFR) ) in people with type 1 diabetes
Authors' conclusion
Interactions between sex and ethnicity may determine the heterogeneity in kidney function decline.
Study context
- Population
- People with T1D and baseline eGFR ≥45 mL/min/1.73 m²; 48% men (81% White, 12% African-Caribbean, 7% Other)
- Participants
- 1,495 people
- Exposure
- Sex and ethnicity groups
- Outcome
- Sex-specific eGFR trajectories and role of sex and ethnicity interaction in predicting eGFR decline
- Follow-up
- 10 years
Methodological detailsgroup-based trajectory modelling, linear mixed models
- Group-based trajectory modelling
- Linear mixed models
Main finding
As reported in the abstract
Rapid eGFR decline (>3 mL/min/1.73 m²/year)
- Five eGFR trajectories identified in both women and men
- 5
- Rapid decline, African-Caribbean women
- 12.3%
- Rapid decline, White women
- 4.8%
- Rapid decline, African-Caribbean men
- 24.3%
- Rapid decline, Asian men
- 22.2%
- Rapid decline, White men
- 8.3%
Observational data: associations, not effects.
Further findings
Mild/Stable eGFR decline
| Outcome | Difference (mL/min/1.73 m²/year) (95% CI) | |
|---|---|---|
| Mean eGFR, African-Caribbean vs White (by sex)African-Caribbean womenvs White women | −20 (−25 to −15) | |
| Mean eGFR, African-Caribbean vs White (by sex)African-Caribbean menvs White men | −15 (−21 to −9) | |
| −30−20−10010Difference, mL/min/1.73 m²/year (linear scale) |
Mean eGFR, African-Caribbean vs White (by sex)
- Lowest eGFR sex gap in African-Caribbeans, highest in 'Other'
Original publication
The role of sex and ethnicity in the variability of estimated glomerular filtration rate ( eGFR ) in people with type 1 diabetes. Diabet Med. Published 31 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →