The risk of fracture among women starting selective serotonin reuptake inhibitors
Main finding · Any fracture incidence (per 100 person-years)Result — go to the resultHazard ratio 1.77 95% CI 1.15–2.74Authors' conclusion
Initiation of SSRI among women in mid-life was associated with an increased risk of fracture.
Study context
- Population
- Diverse US women transitioning across the menopause, Study of Women's Health Across the Nation (SWAN)of 3302 in SWAN
- Participants
- 1,849 women
- Exposure
- SSRI initiation vs no antidepressant
- Outcome
- Any fracture
Methodological detailsmultivariable Cox regression with increasing adjustment, matched
- Multivariable Cox regression with increasing adjustment
- Matched
Main finding
Any fracture incidence (per 100 person-years)
Hazard ratio
1.77
95% CI 1.15–2.74
By group
SSRIvs No AD
HR 1.77 (95% CI 1.15–2.74)
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Results consistent for non-traumatic fractures and in subgroups with BMD included as a covariate
Original publication
The risk of fracture among women starting selective serotonin reuptake inhibitors. J Bone Miner Res. Published 4 August 2025. doi:10.
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