Estimating Net Bone Formation Relative to Resorption Using Reference Bone Turnover Markers
An erratum to this article was published (J Clin Endocrinol Metab, 18 Nov 2025 ↗)
Authors' conclusion
When combined as a BBI, CTX and PINP estimate bone balance; more negative BBI predicts faster BMD loss. Separately, CTX or PINP reflect overall amount of bone turnover; greater CTX or PINP are related to more bone loss.
Study context
- Population
- Women transitioning through menopause, Study of Women's Health Across the Nation
- Participants
- 535 women
- Outcome
- Annualized percent change in lumbar spine (LS) and femoral neck (FN) BMD
Methodological detailsmixed effects linear regression
- Mixed effects linear regression
Main finding
As reported in the abstract
Bone balance index (BBI) and annual BMD change
Greater annual lumbar spine (LS) bone mineral density (BMD) decline per SD decrement in bone balance index (BBI)
0.26%
P < .0001
Greater annual femoral neck (FN) BMD decline per SD decrement in BBI
0.42%
P < .0001
Observational data: associations, not effects.
Further findings
log2CTX and annual BMD decline
- Greater annual LS BMD decline per SD increment in log2CTX
- 0.37% (P < .0001)
- Greater annual FN BMD decline per SD increment in log2CTX
- 0.47% (P < .0001)
- Separate models
log2PINP and annual BMD loss
- Greater annual LS BMD loss per SD increment in log2PINP
- 0.22% (P < .0001)
- Greater annual FN BMD loss per SD increment in log2PINP
- 0.19% (P = .01)
- Separate models
Original publication
Estimating Net Bone Formation Relative to Resorption Using Reference Bone Turnover Markers. J Clin Endocrinol Metab. Published 5 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →