Fasting and postprandial oxytocin and incretin dynamics in women with polycystic ovary syndrome and healthy controls
Authors' conclusion
Women with PCOS show lower fasting oxytocin and incretin levels and impaired postprandial responses. The correlation between oxytocin and GLP-1 indicates a potentially shared pathway in appetite regulation, which may be altered in PCOS and warrants further investigation.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) and age- and BMI-matched healthy controls undergoing a mixed meal test (MMT) in the early follicular phase
- Participants
- 36 vs 36
- Exposure
- Women with PCOS vs healthy controls
- PCOSn = 36
- Controlsn = 36reference
- Outcome
- Baseline oxytocin
- Follow-up
- Baseline
Methodological detailsage- and BMI-matched controls
- Age- and BMI-matched controls
Main finding
As reported in the abstract
P = 0.024
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| GLP-1: baseline and AUCPCOS vs Controls · reduced with PCOS | P < 0.001 |
| GLP-1: baseline and AUCPCOS vs Controls · reduced with PCOS | P = 0.022 |
| GIP: baseline and AUCPCOS vs Controls · reduced with PCOS | P < 0.001 |
| GIP: baseline and AUCPCOS vs Controls · reduced with PCOS | P = 0.033 |
| Food Craving Questionnaire (FCQ) scoresHigher with PCOS | P < 0.001 |
Postprandial oxytocin response to MMT · 30 min
- Oxytocin declined within 30 min in controls but remained unchanged in PCOS
Oxytocin–GLP-1 correlation · all time points
- Oxytocin and GLP-1 significantly correlated at all time points
Oxytocin changes vs hunger and satiety · early
- In controls only, early oxytocin changes correlated negatively with hunger and positively with satiety
Original publication
Fasting and postprandial oxytocin and incretin dynamics in women with polycystic ovary syndrome and healthy controls. Eur J Endocrinol. Published 31 July 2025. doi:10.
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