The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents
Authors' conclusion
Nonfasting insulin sensitivity measures are more reproducible than fasting insulin sensitivity measures, regardless of weight category. Insulin secretion measures have poor reproducibility overall. Weight status, sex, race, and midpubertal stage do not impact the reproducibility of insulin sensitivity and secretion measures.
Study context
- Population
- Children without diabetes aged 8–17 years, overweight/obese and normal weight
- Participants
- 257 children
- Exposure
- Reproducibility of fasting vs oral glucose tolerance test (OGTT)-derived insulin sensitivity and secretion measures
- Overweight/obesen = 186
- Normal weightn = 71reference
- Outcome
- Reproducibility of insulin sensitivity measures
Methodological detailstest–retest: two OGTTs within 3 weeks, clinical research unit
- Test–retest: two OGTTs within 3 weeks
- Clinical research unit
Main finding
As reported in the abstract
- For insulin sensitivity, the OGTT-derived measure was more reproducible than the fasting measures
Observational data: associations, not effects.
Further findings
- No significant differences in reproducibility in overweight/obese vs normal weight, nor by sex, race or pubertal status
Original publication
The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents. Pediatr Diabetes. Published 30 April 2024. doi:10.
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