The obesity paradox in younger adult patients with sepsis: analysis of the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
An erratum to this article was published (Int J Obes (Lond), Sep 2024 ↗)
Authors' conclusion
Contrary to findings regarding older patients with sepsis, our findings suggest that the obesity paradox does not apply to younger adult patients with sepsis.
Study context
- Population
- ICU patients with sepsis (Sepsis-3: SOFA score ≥2 and suspected infection at ICU admission), MIMIC-IV database; younger adults aged <50 years vs older patients aged ≥50 years2,642 aged <50 years
- Participants
- 18,120 patients
- Exposure
- Obesity vs non-obesity in younger adult patients with sepsis
- Outcome
- In-hospital mortality
Methodological detailsMIMIC-IV database, propensity score matching, multivariate logistic regression
- MIMIC-IV database
- Propensity score matching
- Multivariate logistic regression
Main finding
As reported in the abstract
In-hospital mortality, younger adults (<50 years), after propensity score matching
P = 0.457
Observational data: associations, not effects.
Further findings
| Outcome | aOR | P value |
|---|---|---|
| Mortality (Kaplan-Meier), younger adults (<50 years)Obesity not associated with improved mortality | log-rank test: P = 0.197 | |
| Mortality (Kaplan-Meier), older patients (≥50 years)Survival benefit with obesity | log-rank test: P < 0.001 | |
| In-hospital mortality by BMI category, younger adults (<50 years), multivariate logistic regressionUnderweight vs Normal weight · normal weight as reference | 1.72 | P = 0.076 |
| In-hospital mortality by BMI category, younger adults (<50 years), multivariate logistic regressionOverweight vs Normal weight · normal weight as reference | 0.88 | P = 0.437 |
| In-hospital mortality by BMI category, younger adults (<50 years), multivariate logistic regressionObesity vs Normal weight · normal weight as reference | 0.93 | P = 0.677 |
| In-hospital mortality by BMI category, younger adults (<50 years), multivariate logistic regressionSevere obesity vs Normal weight · normal weight as reference | 1.22 | P = 0.580 |
In-hospital mortality by BMI category, younger adults (<50 years), multivariate logistic regression
- BMI was not an independent risk factor for in-hospital mortality in younger adults
Original publication
The obesity paradox in younger adult patients with sepsis: analysis of the MIMIC-IV database. Int J Obes (Lond). Published 26 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →