The Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison′s Disease
Authors' conclusion
Non-restorative sleep emerged as a distinct feature of AAD. While the prevalence and severity of sleep impairments were similar to controls, the association with poorer physical health was stronger in patients. Mental health remained similar despite sleep disturbances. These findings highlight the importance of addressing even modest sleep disturbances, which may worsen fatigue and reduce physical wellbeing in AAD.
Study context
- Population
- Young adults with autoimmune Addison's disease (AAD) and healthy controls
- Participants
- 64 vs 128
- Exposure
- Young adults with AAD vs healthy controls
- AADn = 64
- Healthy controlsn = 128reference
- Outcome
- Self-reported sleep impairments (Karolinska Sleep Questionnaire) and their associations with fatigue (Multidimensional Fatigue Inventory) and HRQoL (Short Form-36)
Main finding
As reported in the abstract
Sleep (Karolinska Sleep Questionnaire)
- Overall rates of clinically relevant sleep impairments were similar
- AAD vs Healthy controls: P = 0.015
- AAD vs Healthy controls: P = 0.011
- AAD vs Healthy controls: P = 0.036
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Physical health (SF-36)Poorer with AAD | P < 0.001 |
| General fatigue (MFI)Greater with AAD | P = 0.007 |
| Mental fatigue, femalesMore in female patients | P = 0.013 |
Associations of sleep and fatigue with health-related quality of life (HRQoL)
- Poor sleep and fatigue associated with reduced HRQoL across the cohort; more pronounced decline in physical health in patients
Mental health (SF-36)
- Mental health scores remained similar between groups
Original publication
The Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison′s Disease. Clin Endocrinol (Oxf). Published 2 September 2025. doi:10.
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