Outcomes of stereotactic radiosurgery in nelson’s syndrome: a systematic review and Meta-Analysis
Authors' conclusion
SRS provides high local control rates and a low safety risk for NS patients, although endocrine remission remains limited. These results support SRS as a viable choice in multidisciplinary management, although further prospective studies are needed.
Study context
- Population
- Patients with Nelson's syndrome after bilateral adrenalectomy for Cushing's disease (CD)
- Participants
- 122 patients7 studies
- Outcome
- Pooled local control (LC) after SRS
Methodological detailsPRISMA guidelines, PubMed, Embase, Scopus and Web of Science searched through June 11, 2025
- PRISMA guidelines
- PubMed, Embase, Scopus and Web of Science searched through June 11, 2025
Pooled result
As reported in the abstract
Pooled local control (LC)
95%
95% CI 89–99%
Safety
Adverse radiation effects (ARE)
- Pooled ARE
- 0% (95% CI: 0-11%)
- Larger lesion volume, longer interval from prior resection and higher pre-SRS ACTH levels significantly associated with increased ARE risk (meta-regression)
New pituitary dysfunction (NPD)
- Pooled NPD
- 20% (95% CI: 11-31%)
Original publication
Outcomes of stereotactic radiosurgery in nelson’s syndrome: a systematic review and Meta-Analysis. Pituitary. Published 30 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →