The prevalence and associated risk factors of detectable renal morphological abnormalities in acromegaly
Authors' conclusion
The results of this study showed that acromegaly disease significantly increased the prevalence of SRCs and kidney length compared to the age-sex matched healthy population, while the prevalence of KSD was similar. Advanced age and male gender were seen to be independent risk factors for SRC formation in patients with acromegaly.
Study context
- Population
- Patients with acromegaly and age-sex matched healthy individuals, single centre
- Participants
- 125 vs 114
- Comparison
- Acromegaly vs age-sex matched healthy individuals
- Acromegalyn = 125
- Controln = 114reference
- Outcome
- Prevalence of simple renal cysts (SRCs) and kidney stone disease (KSD)
Methodological detailssingle-centre, age-sex matched controls
- Single-centre
- Age-sex matched controls
Main finding
As reported in the abstract
SRC prevalence
P < 0.001
- Acromegaly increased the risk of SRC formation
- 12.8-fold
Observational data: associations, not effects.
Further findings
KSD prevalence · similar
P = 0.08
- Longitudinal and transverse kidney lengths · significantly higher with acromegaly
- P < 0.05
Acromegaly with vs without renal cysts
- Patients with cysts (n = 36) vs without (n = 89): older, more often male, longer pre-diagnosis symptom duration, more hypertension and DM at diagnosis
- Multivariate logistic regression: only advanced age and male gender associated with simple renal cysts (SRCs)
Original publication
The prevalence and associated risk factors of detectable renal morphological abnormalities in acromegaly. Pituitary. Published 8 December 2023. doi:10.
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