The spectrum of cardiac abnormalities in patients with acromegaly: results from a case-control cardiac magnetic resonance study
Authors' conclusion
The CMR analysis reveals a cluster of biventricular structural and functional impairment in acromegaly, even when the biochemical control if achieved. These findings appear specifically triggered by the exposure to GH-IGF1 excess and show sex-related differences advocating a possible interaction with sex hormones in cardiac disease progression.
Study context
- Population
- Consecutive patients with acromegaly (7 females, mean age 50 years), cured after surgery or on medical treatment
- Participants
- 20 vs 17
- Comparison
- Acromegaly vs matched controls with non-functioning adrenal incidentalomas
- Acromegalyn = 20
- Controlsn = 17reference
- Outcome
- Cardiac morpho-functional parameters on cardiac magnetic resonance (CMR)
Methodological detailsmulticentre, cardiac magnetic resonance
- Multicentre
- Cardiac magnetic resonance
Main finding
As reported in the abstract
- Acromegaly vs Controls: P < 0.001
- Acromegaly vs Controls: P = 0.001
- Acromegaly vs Controls: P = 0.028
- Acromegaly vs Controls: P = 0.002
- Acromegaly vs Controls: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| LVMi and interventricular septum thickness, male vs female patients (subgroup)Male vs Female · LVMi higher in males | P = 0.025 |
| LVMi and interventricular septum thickness, male vs female patients (subgroup)Male vs Female · Interventricular septum thickness higher in males | P = 0.003 |
- LVMi and interventricular septum thickness, male vs female patients (subgroup): even after adjusting cardiac parameters for confounding factors
Cardiometabolic comorbidities
- No significant differences in prevalence of hypertension, glucose and lipid metabolism impairment, obstructive sleep apnoea syndrome and obesity
IGF-1 × upper limit of normal as predictor of LVMi
- IGF-1 × ULN significantly predicted LVMi (b)
- 0.575; p = 0.008
Original publication
The spectrum of cardiac abnormalities in patients with acromegaly: results from a case-control cardiac magnetic resonance study. Pituitary. Published 7 June 2024. doi:10.
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