Pituitary & hypothalamus

Importance of 24 h ambulatory blood pressure monitoring in patients with acromegaly and correlation with cardiac magnetic resonance findings

PituitaryPublished Cross-sectional study

Authors' conclusion

We observed, that 24 h-ABPM in acromegaly allows the diagnosis of AH in some patients with normal BP in OBP and also to allow a better treatment. 24 h-ABPM shows a better correlation with VM by CMR.

Study context

Population
Patients over 18 years of age with acromegaly; treatment-naïve patients underwent cardiac magnetic resonance
Participants
96 participants
Exposure
24 h-ABPM vs office blood pressure for diagnosing arterial hypertension
Outcome
Frequency of arterial hypertension measured by 24 h-ABPM vs OBP, and correlation of BP with cardiac mass

Main finding

As reported in the abstract

Arterial hypertension by 24 h-ABPM vs OBP

Non-hypertensive by office blood pressure (OBP) with arterial hypertension (AH) on 24 h-ABPM

9 of 29

Previous AH diagnosis by OBP: controlled BP on 24 h-ABPM

25

Previous AH diagnosis by OBP: abnormal BP on 24 h-ABPM

42

Previous AH diagnosis by OBP: controlled BP by OBP

28

Observational data: associations, not effects.

Further findings

Correlates of diastolic BP on 24 h-ABPM

Positive correlation of diastolic BP on 24 h-ABPM with IGF-1 levels; no correlation with age, sex, BMI or GH levels

Correlation of BP with left ventricular mass by cardiac magnetic resonance (CMR)

CMR performed
11 patients
Positive correlation of left ventricular mass (LVM) with BP of 24 h-ABPM; no correlation of OBP with CMR parameters

Original publication

Importance of 24 h ambulatory blood pressure monitoring in patients with acromegaly and correlation with cardiac magnetic resonance findings. Pituitary. Published 29 May 2023. doi:10.1007/s11102-023-01321-8

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