Clinical and imaging findings for the evaluation of large Rathke’s cleft cysts and cystic craniopharyngiomas
Authors' conclusion
LRCCs can be differentiated from CCPs based on their clinical and imaging findings, especially their specific anatomical growth patterns. We suggest using the pretreatment diagnosis to select the appropriate surgical approach and thus improve the clinical outcome.
Study context
- Population
- Patients with Large Rathke's cleft cysts (LRCCs) or cystic craniopharyngiomas (CCPs) with maximal diameter >20 mm
- Participants
- 20 vs 25
- Exposure
- Large Rathke's cleft cysts vs cystic craniopharyngiomas
- LRCCsn = 20
- CCPsn = 25reference
- Outcome
- Clinical and MR imaging findings
Main finding
As reported in the abstract
- Age of onset, LRCCs vs CCPs (years)
- 49.0 ± 16.8 vs 34.2 ± 22.2; p = .022
- Solid component, LRCCs vs CCPs
- 7/20 (35%) vs 21/25 (84%); p = .001
- Thick cyst wall, LRCCs vs CCPs
- 2/20 (10%) vs 12/25 (48%); p = .009
- Intracystic septation, LRCCs vs CCPs
- 1/20 (5%) vs 8/25 (32%); p = .030
- Snowman shape, LRCCs vs CCPs
- 18/20 (90%) vs 1/25 (4%); p < .001
- Off-midline extension, LRCCs vs CCPs
- 0/0 (0%) vs 10/25 (40%); p = .001
- Oblique angle of sagittal long axis, LRCCs vs CCPs
- 89.9° vs 107.1°; p = .001
Observational data: associations, not effects.
Further findings
Postoperative diabetes insipidus
P = 0.006
Posttreatment recurrence
P = 0.025
Original publication
Clinical and imaging findings for the evaluation of large Rathke’s cleft cysts and cystic craniopharyngiomas. Pituitary. Published 25 May 2023. doi:10.
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