Diabetes complications

The predictive value of cumulative plantar tissue stress on future plantar foot ulceration in people with diabetes—A 12‐month prospective observational study

Diabet MedPublished Prospective observational cohort study

Authors' conclusion

CPTS did not predict plantar foot ulceration in our high-risk participants, but our findings support the mechanical pathway of plantar foot ulceration through pre-ulcer development and indicate lower walking speed as an important predictor. Assessing walking speed and early identifying and treating pre-ulcers will help predict and prevent plantar foot ulcers in high-risk people with diabetes.

Study context

Population
People with diabetes at high foot ulcer risk
Participants
60 people
Outcome
Plantar foot ulceration
Follow-up
12-month follow-up
Methodological details12-month follow-up
  • 12-month follow-up

Main finding

As reported in the abstract

Plantar forefoot ulcer; predictors (multivariate regression) · 12 months

Developed a plantar forefoot ulcer

22

37%

Cumulative plantar tissue stress (CPTS) as predictor, OR

0.90 (0.50-1.59) (95% CI)

Pre-ulcers at baseline as predictor, OR

9.97 (1.41-70.65) (95% CI)

Walking speed (m/s) as predictor, OR

0.01 (0.00-0.32) (95% CI)

Observational data: associations, not effects.

Further findings

CPTS associated with pre-ulcers, OR
2.38 (1.02-5.54) (95% CI)
  • Significant association

Original publication

The predictive value of cumulative plantar tissue stress on future plantar foot ulceration in people with diabetes—A 12‐month prospective observational study. Diabet Med. Published 31 July 2025. doi:10.1111/dme.70099

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