The Obese Taste Bud study: Objectives and study design
Authors' conclusion
Initial findings suggest that metabolic alterations are relevant for taste and smell function and TBD. By combining omics data from collected biomaterial with physiological, metabolic and psychological data related to taste perception and eating behaviour, the OTB study aims to strengthen our understanding of taste perception in obesity.
Study context
- Population
- Participants with overweight, obesity or normal weight, University of Leipzig Obesity Centre
- Outcome
- Associations with taste bud density (TBD), taste perception and olfactory function
- Follow-up
- Baseline
Methodological detailsstudy design and baseline characteristics, single-centre, Launched in 2020 at the University of Leipzig Obesity Centre with the HI-MAG Institute, Taste and smell tests, anthropometry, taste bud density (TBD) assessment, fasting biomaterial, glucose tolerance test, stool sample, taste bud biopsy; fMRI subsample, Follow-up after conventional weight loss interventions and bariatric surgery planned
- Study design and baseline characteristics
- Single-centre
- Launched in 2020 at the University of Leipzig Obesity Centre with the HI-MAG Institute
- Taste and smell tests, anthropometry, TBD assessment, fasting biomaterial, glucose tolerance test, stool sample, taste bud biopsy; fMRI subsample
- Follow-up after conventional weight loss interventions and bariatric surgery planned
Main finding
As reported in the abstract
- HbA1c levels and age negatively associated with TBD
- Unfavourable metabolic profile, current dieting and vegan diet related to taste perception
- Olfactory function negatively correlates with age and HDL-C
- Initial results
Observational data: associations, not effects.
Original publication
The Obese Taste Bud study: Objectives and study design. Diabetes Obes Metab. Published 15 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →