The interaction effect between BMI , diabetes and age at diabetes onset on the risk of thyroid cancer: A population‐based cohort study in Shanghai, China
Main finding · Thyroid cancer risk in T2DM vs general populationResult — go to the resultStandardized incidence ratio 1.21Authors' conclusion
Both earlier age of T2DM onset (<50 years) and higher BMI (≥30 kg/m2) contributed to the higher risk of thyroid cancer. Patients with young-onset T2DM and obesity are considered more vulnerable to thyroid cancer development.
Study context
- Population
- Persons with new-onset T2D, Shanghai, China, matched with the general population
- Participants
- 428,568 persons
- Exposure
- Persons with new-onset T2D vs general population; by age at T2D onset and BMI
- New-onset T2DMn = 428,568
- Outcome
- Thyroid cancer risk (SIR, HR)
- Follow-up
- 8 years
Methodological detailsregister-based, longitudinal, matched with the general population
- Register-based
- Longitudinal
- Matched with the general population
Main finding
As reported in the abstract
Thyroid cancer risk in T2DM vs general population
Standardized incidence ratio
1.21
- Thyroid cancer cases identified
- 1142
- Incidence rate
- 59.01/100 000 person-years
- Highest risk with both BMI ≥30.0 kg/m² and onset age <50 years: Standardized incidence ratio (SIR)
- 3.91
- Highest risk with both BMI ≥30.0 kg/m² and onset age <50 years: HR
- 3.04
Observational data: associations, not effects.
Further findings
Thyroid cancer by age at T2D onset and BMI
- SIR, onset age <50
- 1.46
- SIR, BMI ≥30.0 kg/m²
- 1.93
- SIR, BMI ≥30.0 kg/m² and onset age <50 years
- 3.91
- HR, BMI ≥30.0 kg/m² and onset age <50 years
- 3.04
- Onset age <60 years: SIR increased with higher BMI; no trends when onset age ≥60 years
- BMI ≥25.0 kg/m²: SIR increased with earlier onset age; no trends with BMI <24.9 kg/m²
- Obese (BMI ≥30.0 kg/m²): significantly higher HR only when T2D onset age <60 years
Original publication
The interaction effect between BMI , diabetes and age at diabetes onset on the risk of thyroid cancer: A population‐based cohort study in Shanghai, China. Diabetes Obes Metab. Published 8 July 2024. doi:10.
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