The impact of mild hypoxia exposure on myokine secretion in human obesity
Authors' conclusion
Hypoxia exposure altered the secretion of several myokines in primary human myotubes, revealing hypoxia as a novel modulator of myokine secretion. However, both acute and 7-day MIH exposure did not induce alterations in plasma myokine concentrations in individuals with overweight and obesity.
Study context
- Population
- Individuals with overweight and obesity (BMI ≥ 28 kg/m²); differentiated primary human myotubescrossover
- Participants
- 12 individuals
- Comparison
- Hypoxia vs normoxia
- Outcome
- Myokine secretion and SM pO2
Methodological detailsin vitro primary human myotubes, randomized single-blind crossover trial
- In vitro primary human myotubes
- Randomized single-blind crossover trial
Main finding
As reported in the abstract
- 1% vs 3% O2 in myotubes: increased secreted protein acidic and rich in cysteine (SPARC) secretion
- p = 0.043
- 1% vs 3% O2 in myotubes: increased FSTL1 secretion
- p = 0.021
- 1% vs 3% O2 in myotubes: reduced leukemia inhibitory factor (LIF) secretion
- p = 0.009
- 1% vs 21% O2 in myotubes: increased IL-6 secretion
- p = 0.004
- 1% vs 21% O2 in myotubes: increased SPARC secretion
- p = 0.021
- 1% vs 21% O2 in myotubes: reduced FABP3 secretion
- p = 0.021
- MIH in vivo markedly decreased skeletal muscle (SM) pO2 (≈40%)
- p = 0.002
Original publication
The impact of mild hypoxia exposure on myokine secretion in human obesity. Int J Obes (Lond). Published 30 March 2023. doi:10.
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