The impact of insulin resistance on thyroid function and the prevalence of thyroid follicular nodular disease in pregnant women
Authors' conclusion
IR seems to affect the thyroid function of gravid women by diminishing the ability to respond to increased thyroid hormone demand. Thyroid volume increase during pregnancy may be influenced by IR; however, its short-term effect on thyroid nodularity appears to be negligible.
Study context
- Population
- Pregnant participants of the Polish National Programme for Elimination of Iodine Deficiency (2007–2017)US in 1,065
- Participants
- 1,069 participants
- Exposure
- Homeostatic model assessment of insulin resistance (HOMA-IR) ≥2.5 vs HOMA-IR <2.5
- HOMA-nln = 894reference
- HOMA-hn = 175
- Outcome
- Thyroid function by HOMA-IR subgroup
Main finding
As reported in the abstract
- Thyroid nodularity and multinodular goiter prevalence did not differ between subgroups
- HOMA-IR positively correlated with thyroid-stimulating hormone (TSH), BMI and thyroid volume
- FT3 and FT4 negatively correlated with HOMA-IR
- HOMA-h vs HOMA-nl: P = 0.008
- HOMA-h vs HOMA-nl: P = 0.001
Observational data: associations, not effects.
Original publication
The impact of insulin resistance on thyroid function and the prevalence of thyroid follicular nodular disease in pregnant women. Eur Thyroid J. Published 18 March 2025. doi:10.
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