Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans
Authors' conclusion
Serum scEMC10 levels are inversely associated with BAT activity in humans.
Study context
- Population
- Participants with or without active brown adipose tissue (BAT) on PET-CT, participants with positive BAT before and after thermoneutrality, and patients with GD-caused hyperthyroidism before and after anti-thyroid drug (ATD) treatment; Chinese and White cohorts
- Comparison
- Positive vs negative BAT; before vs after thermoneutrality; before vs after ATD treatment
- Outcome
- Serum scEMC10 levels
Methodological detailsmultiple cohorts
- Multiple cohorts
Main finding
As reported in the abstract
Serum scEMC10
- Serum scEMC10 significantly elevated by 2-h thermoneutrality in positive BAT, with disappearance of active BAT
- p = 0.0017
Further findings
Age and adiposity by BAT status
- Positive BAT participants significantly younger and leaner than negative BAT
Original publication
Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans. Int J Obes (Lond). Published 18 March 2025. doi:10.
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