The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis
Authors' conclusion
Left ventricular performance is compromised in overt CS beyond alterations found in individuals with metabolic syndrome sharing equal CV risk factors and remains so despite biochemical remission during the LTR period. Myocardial Work analysis is suited to detect the subtle yet clinically relevant differences between different phenotypes of myocardial involvement.
Study context
- Population
- Patients with overt or remitted endogenous Cushing's syndrome (CS), healthy subjects and individuals with metabolic syndrome; LV performance by echocardiographic Myocardial Work analysis
- Participants
- 31 / 49 / 439 / 305
- Exposure
- Overt CS and CS in long-term remission vs healthy subjects and individuals with metabolic syndrome
- Overt CSn = 31
- CS-LTRn = 49
- Healthyn = 439reference
- Metabolic syndromen = 305reference
- Outcome
- Wasted Work (LV myocardial work)
Methodological detailsadjusted for sex and age
- Adjusted for sex and age
Main finding
As reported in the abstract
Overt CS and CS-LTR vs Healthy: P < 0.01 · Overt CS and CS-LTR vs Metabolic syndrome: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Work EfficiencyOvert CS and CS-LTR vs Healthy subjects and Metabolic syndrome · compromised Work Efficiency in CS groups | P < 0.05 |
Cardiovascular (CV) risk pattern and metabolic profile
- Both CS groups had a CV risk and metabolic profile worse than healthy subjects but better than metabolic syndrome
Original publication
The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis. Cardiovasc Diabetol. Published 21 March 2025. doi:10.
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